Symmetric dimethylarginine (SDMA)
SDMA is a biomarker for kidney function
SDMA is a methylated arginine that is produced endogenously by all nucleated cells in the body and excreted by the kidneys. It is released into circulation when intracellular proteins are processed. Stable production of SDMA is part of daily cell activity.
Trust SDMA for greater efficiency than creatinine and BUN testing
Historically, estimation of renal function has depended on various methods such as Glomerular Filtration Rate (GFR), BUN and creatinine. SDMA has been shown to correlate with GFR and is not subject to extra renal factors such as age and muscle mass. SDMA has also been shown to detect loss of kidney function earlier than creatinine.
LCMS gold standard methodology
The gold standard methodology for measuring SDMA is Liquid Chromatography Mass Spectrometry (LCMS), which has shown good correlation with glomerular filtration rate. Mass spectrometry, often referred to as mass spec, is an advanced analytical technique that is highly sensitive. LCMS is used to accurately identify and quantify molecules within a sample.
SDMA has been validated in dogs, cats, horses and rats (Other species are currently in process) through a comparison to the LCMS. All species validations utilize LCMS as the gold standard.
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